Cell-cell connections are far stronger than cell-substrate connections. The proteins that cells use to connect to non-cellular material are weaker than the proteins used in cell-cell connections. On a large scale, this means that the junction between percutaneous implants and living tissue is weak and prone to infection. The weak connection offers opportunities for bacteria and other material to bypass the skin, infecting deeper tissues. There are many approaches to improve this junction, but most fall short in one way or another. However, with the introduction of the 3D printer known as the Nanoscribe, one can create incredibly intricate structures on a cellular level. The Nanoscribe uses two photon technology to polymerize resin on a micrometer scale. The structures it creates are incredibly intricate and a step above and beyond the 2D or 2.5D fabrication techniques that are in standard use. The Nanoscribe has been used for biological applications before and has been shown to create structures that operate on a single cell. One application of this technology to the implant infection issue could be found in the creation of arches. Tiny arches on an implant would allow a cell to wrap around the structure and create a junction of cellular self-contact under the arch. This contact would produce the stronger cell-cell protein and connect the larger to the substrate in a much stronger way. The trick is to maximize that strength and figure out what dimensions are favorable to induce self contact and overall tissue connection strength.