Drugs are good, but how do they go bad?, Yejoon Seo, G4 (3937727)
Many oral delivery drugs are in the amorphous state, stabilized by an amorphous polymer. Over time, these drugs tend to "flow," resulting in significant changes to the drug product that severely reduces its therapeutic efficacy. This poses a challenge to the trillion-dollar pharmaceutical industry and, to some extent, affects everyone around the world. Our lab has discovered that the understanding of how the amorphous polymer "flows" is essential to the drug formulation and its expected shelf life. We primarily employ thermal analysis, where we subject the polymer to different temperature conditions and track the energy changes of the system to quantify this "flow." With my research, I hope to provide the data necessary to support an ideal world where there are no medicines that go bad.