Biomedical devices that penetrate the skin, such as implants and vascular access devices, rely on a stable attachment between the tissue and material to prevent complications. If the adhesion fails at the tissue-material interface, it can cause gaps and down-growth of skin cells below the implant, leading to infection and inflammation at the insertion site. To address this issue, we propose using E-cadherin coating as a potential solution to improve attachment at the interface by mimicking natural cell-cell adhesion. E-cadherin is a crucial protein for cell-cell adhesion, enabling cells to bond with their neighboring cells. We conducted a simplified system by coating a dual surface of conventional collagen surface (control) and E-cadherin, followed by the seeding of epithelial cells on top of this surface. Our results confirmed that the tissue formed a cell-cell junction with our artificial E-cadherin substrate, but not with the collagen surface. Additionally, the cells on the E-cadherin side of the surface exhibited slower migration and proliferation than those on the collagen surface. Our basic testing with cadherin surface and cultured tissue demonstrated the potential of E-cadherin coating as a biological glue for improved adhesion.