In an increasingly polluted world, anthropogenic contaminants have become a significant threat to wildlife globally. Entering an organism through water, soil, food, and air, these toxic chemicals alter biological functioning and can act as a source of human-mediated selection in chronically exposed populations. Uncovering the mechanisms by which this selection may impose adaptive resistance to toxic contaminants can help to understand and predict the long-term evolutionary consequences of exposure. Studies on wildlife inadvertently exposed to chronic levels of contaminants are ideal study subjects for documenting biological responses to exposure. However, few studies have connected these adverse responses across the biological hierarchy to help identify the underpinning mechanisms of adaptation. In my research, I utilize crocodilian systems as a sentinel for contamination to examine transcriptomic responses and possible mechanisms of adaptation in response to one of the most ubiquitous sources of pollution today: pesticides.