My research focuses on the study of the neural basis of human cognition, particularly decision-making, through the examination of invasive brain activity in neurosurgical patients. I combine human electrophysiological and electrochemical recordings during decision-making tasks with computational models of reward and choice. This experimental combination provides access to fast, highly detailed, high signal-to-noise, multi-areal neural activity from the human brain, which is highly suited to studying the relationship of distributed neural activity to aspects of cognition and the use of neurostimulation techniques to modulate behavior and treat cognitive aspects of disease. In this talk, I will cover the different methodologies we employ in the lab, as well as current research efforts in the study of decision-making and the combination of computational psychiatry and intracranial approaches.