Proteins change their structure to perform different functions. We have always known that proteins can exist in different structures but the molecular mechanisms that allow parts of a protein to talk to each other are not known. It is an important fundamental question because it would allow us to track the behavior of a protein at different points in time. Does Seratonin interact better with anti-depressants in the morning because sunlight changes its structure? By simulating the chemical movements of a protein and using biomechanical models to generate every transient structure possible, we can put together the path taken by a protein to go from one structure to the other at different times. We find that proteins have well-defined highways inside them that allow different parts to trigger a very specific movement that ripples through the protein and changes its structure.